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pfizer multiparameter optimization system  (Pfizer Inc)
86
Pfizer Inc pfizer multiparameter optimization system
( A ) Radar plot of <t>multiparameter</t> optimization (MPO) criteria, ( B ) alignment between logD at pH 7.4 and MW for estimation of effective cell permeability profile (P app,A→B ) and intrinsic hepatic clearance (Cl int,u ), and ( C ) prediction of cell effective permeability (PAMPA) for the compounds LASSBio-2123, LASSBio-2124, LASSBio-2125, LASSBio-2129, LASSBio-2130, and the reference drug, sitagliptin.
Pfizer Multiparameter Optimization System, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 86 stars, based on 1 article reviews
pfizer multiparameter optimization system - by Bioz Stars, 2026-05
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( A ) Radar plot of multiparameter optimization (MPO) criteria, ( B ) alignment between logD at pH 7.4 and MW for estimation of effective cell permeability profile (P app,A→B ) and intrinsic hepatic clearance (Cl int,u ), and ( C ) prediction of cell effective permeability (PAMPA) for the compounds LASSBio-2123, LASSBio-2124, LASSBio-2125, LASSBio-2129, LASSBio-2130, and the reference drug, sitagliptin.

Journal: Pharmaceuticals

Article Title: Unraveling the Antihyperglycemic Effects of Dipeptyl Peptidase-4 Inhibitors in Rodents: A Multi-Faceted Approach Combining Effects on Glucose Homeostasis, Molecular Docking, and ADMET Profiling

doi: 10.3390/ph18101589

Figure Lengend Snippet: ( A ) Radar plot of multiparameter optimization (MPO) criteria, ( B ) alignment between logD at pH 7.4 and MW for estimation of effective cell permeability profile (P app,A→B ) and intrinsic hepatic clearance (Cl int,u ), and ( C ) prediction of cell effective permeability (PAMPA) for the compounds LASSBio-2123, LASSBio-2124, LASSBio-2125, LASSBio-2129, LASSBio-2130, and the reference drug, sitagliptin.

Article Snippet: Microsomal clearance values were also low (<8.0 μL/min/mg), supporting the stability profile predicted by the Pfizer multiparameter optimization system [ , ].

Techniques: Permeability, PAMPA Assay